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KMID : 1123920140280060607
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 6 p.607 ~ p.613
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Effect of Mori Folium Extract on Improvement of Blood Flow in Ferric Chloride-Induced Carotid Artery Damage Rat Model
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Kang Hyun-Ju
Jeon In-Hwa
Gwon Tae-Oh
Choi Ji-Won
Kim Sung-Zoo
Jang Seon-Il
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Abstract
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In a previous study, we have shown that mulberry leaves (Mori Folium) extract MFE) and its compounds have the antioxidant effect in human red blood cells. However, the possible effect of MFE and its compounds on improvement of blood flow were not reported. Therefore, the aim of this study is to investigate the effects of MFE and its compounds on improvement of blood flow in a rat model of topical ferric chloride (FeCl3)-induced carotid artery damage. The FeCl3 treatment seriously damaged the carotid artery: the walls of the artery, blood flow rate, blood vessel diameter, blood vessel area and blood flow amount. However, administration of MFE or its compound has ameliorated the blood flow and suppressed thrombus in blood vessels. Moreover, the concentrations of serum total cholesterol, triglycerides, and LDL cholesterol in the MET and its compound groups were remarkably reduced in comparison to the control group, and HDL cholesterol concentration was higher in the MET and its compound groups than in the control group. These results suggest that MFE and its compounds ameliorate the thrombosis against blood vessel damage.
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KEYWORD
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Mori Folium, ferric chloride, carotid artery, blood flow improvement
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